Anti-Abeta (1-40/42) | 4D8 | oligomer specific monoclonal targeting amyloid-beta Antibody
Cat. No.
Y030015
Unit
25 μg
Price
$895.00
Specifications
| Cat. No. | Y030015 |
| Name | Anti-Abeta (1-40/42) | 4D8 | oligomer specific monoclonal targeting amyloid-beta Antibody |
| Clone | Monoclonal |
| Price | $895.00 |
| Unit | 25 μg |
| Category | Monoclonal Antibodies |
| Gene Name | Aβ (1-40-42) |
| Application | IHC,ELISA |
| Application Info | Coating antibody at 2 µg/ml (ELISA), 1: 500 (IHC) |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Human |
| Description | Alzheimer's disease is a progressive neurodegenerative disorder characterized by neurofibrillary tangles and depositionof plaques containing the amyloid-ß (Aß) peptide. Aß is derived through proteolytic cleavage of the amyloid precursor protein resulting in various peptide lengths corresponding to 38-43 amino acids. Aß1-42 is particularly prone to self-aggregate and its aggregates are strongly linked to development of the disease. During in vitro Aß self-assembly, highly cytotoxic metastable intermediates (oligomers) are generated ranging from 8 kDa to over 100 kDa. Several reports suggest a similar situation in vivo. We have generated a monoclonal antibody, specific for Aß oligomers, by immunizing mice with partly aggregated Aß1-40 peptide. The antibody 4D8 is a conformational specific antibody that specifically can detect oligomeric structures of Aß (1-42). The reactivity is strongly enhanced within an oligomeric range of approximately 4-15 Aß monomers while it shows only very low affinity towards mature fibrils and soluble monomers. |
| Immunogen | Partly aggregated, recombinant peptide corresponding to the human Abeta (1-40). Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V |
| Isotype | IgM |
| Concentration | 0.5ug/1ul |
| Recommended Dilutions | Coating antibody at 2 µg/ml (ELISA), 1: 500 (IHC) |
| Storage Buffer | PBS, pH 7.4 with 0.02% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human |
| Specificity | No confirmed exceptions from predicted reactivity known in the moment |
| Purity | Affinity purified |
| Guarantee | abm guarantees that all our Anti-Abeta (1-40/42) | 4D8 | oligomer specific monoclonal targeting amyloid-beta Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Depositor | Agrisera |
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